On 1 July 2015, Liverpool confirmed the signing of Clyne from Southampton for £12.5 million on a five-year contract. Clyne made his debut in a Liverpool shirt against the True Thai Premier League All Stars in Bangkok on 14 July as part of the club's pre-season tour. He made his competitive debut on 10 August in a 1–0 away win against Stoke City in the first match of the 2015–16 Premier League season.

On 8 October 2015, Clyne scored his first Liverpool goal in a 1–0 League Cupfourth round victory over Bournemouth, the team's first win under Jürgen Klopp. His first league goal came on the 14 February, in a 6–0 win at Aston Villa.

In March 2016, in Liverpool's first European games against rivals Manchester United, Clyne won a penalty that Daniel Sturridge converted in the first leg, and conceded a penalty scored by Anthony Martial in the second, as Liverpool won 3–1 on aggregate in the last 16 of the UEFA Europa League.[26] On 18 May, he played the full 90 minutes in the final, a 3–1 loss to Sevilla in Basel.

Clyne was born in Stockwell, London. He began his career at Crystal Palace, playing regularly in four Championship seasons. He made his first-team debut for Crystal Palace in a 3–0 Championship win against Barnsley at Selhurst Park on 18 October 2008. He signed a three-year professional contract with the club two days later. In the 2010–11 season. Clyne was the youngest player in the Football League to play every single game of that campaign, and won Crystal Palace's Player of the Year award.

On 19 July 2012, Clyne signed a four-year deal with newly promoted Premier League side Southampton. He made his debut on 19 August, in a 3–2 defeat against Manchester City. He scored his first goal for the club on 22 September, in a 4–1 win at home against Aston Villa. clyne scored in Southampton's first game of the 2014–15 season, a 2–1 defeat against Liverpool at Anfield on 17 August. Clyne played 94 times for the Saints scoring 3 goals